11/10/2023 0 Comments Graphpad prism 4.03In contrast, diosgenone and SN1 did not inhibit solute-induced haemolysis. SN2 and SN4 inhibited isosmotic sorbitol and alanine-induced haemolysis of pRBCs. However, transmission electron microscopy revealed no effect on the morphology of uninfected erythrocytes treated with either SN2 or diosgenone and neither SN induced haemolysis of uninfected erythrocytes. We found that most merozoites were unable to invade SN-treated erythrocytes. Thus, we assessed alterations in the membranes of uninfected red blood cells, the parasite invasiveness and the solute-induced lysis of parasitised red blood cells (pRBCs). It is well known that steroids can alter the membrane function of erythrocytes. Steroids from Solanum nudum (SNs) have demonstrated antiplasmodial activity against erythrocytic stages of the Plasmodium falciparum strain FCB-2.
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